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Benign signet ring cell change with multilayering in the gallbladder mucosa--a case report

V S Suri1, P Sakhuja, V Malhotra

  • 1Department of Pathology, G.B Pant Hospital, New Delhi, India. suri@bol.net.in

Pathology, Research and Practice
|January 5, 2002
PubMed

Insights

This study reports a rare case of benign signet ring cell change in the gallbladder lining. This finding mimics malignancy but is a non-cancerous condition requiring careful histopathological evaluation.

Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Histopathology

Background:

  • Signet ring cell morphology is typically associated with malignancy.
  • Benign changes can mimic malignant features, posing diagnostic challenges.

Observation:

  • A case of benign signet ring cell change in the gallbladder mucosa is presented.
  • Histopathological examination revealed multilayering epithelium with signet ring-like cells.
  • Cells showed uniform positivity for mucin stains and negativity for fat stains.

Findings:

  • Immunohistochemistry confirmed positivity for pancytokeratin (PCK) and epithelial membrane antigen (EMA).
  • Absence of nuclear atypia, hyperchromatism, and mitotic activity supported a benign diagnosis.
  • This represents the second documented case of benign signet ring cell change in the gallbladder.

Implications:

  • Distinguishing this benign change from in situ adenocarcinoma is crucial.
  • Highlights the importance of comprehensive histopathological assessment in gallbladder pathology.
  • Adds to the literature on rare benign gallbladder mucosal alterations.

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