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Unusual morphology in a case of large granular cell leukemia

S Galimberti1, R Riccioni, A Azzarà

  • 1Hematology Division, Department of Oncology, Transplants and Advanced Technologies, University of Pisa, Ospedale S.Chiara, Via Roma 67, 56100 Pisa, Italy.

Annals of Hematology
|January 18, 2002
PubMed

Insights

Large granular lymphocyte (LGL) disorders involve clonal proliferation of NK or T-cells. This case highlights an unusual CD4+CD8+ T-cell LGL leukemia with distinct bone marrow morphology.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Large granular lymphocyte (LGL) proliferative disorders encompass clonal and nonclonal conditions affecting Natural Killer (NK) or T-cell lineages.
  • These disorders present with shared morphological characteristics but exhibit clinical polymorphism due to cellular differences.

Observation:

  • A rare case of LGL disease was identified.
  • The patient presented with atypical cell morphology in bone marrow.

Findings:

  • The LGL disease exhibited an unusual immunophenotype of CD4+CD8+ clonal T cells.
  • Bone marrow examination revealed atypical cellular morphology.

Implications:

  • This case expands the understanding of LGL disease heterogeneity.
  • Recognizing unusual immunophenotypes like CD4+CD8+ is crucial for accurate diagnosis and management of LGL leukemia.
  • Further research into the cellular and molecular basis of LGL disorders is warranted.

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