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A role for CD147 in thymic development

Toufic Renno1, Anne Wilson, Caroline Dunkel

  • 1Centre d'Immunologie Pierre Fabre, 5 Avenue Napoleon III, Saint-Julien en Genevois, 74160 France.

Journal of Immunology (Baltimore, Md. : 1950)
|May 8, 2002
PubMed

Insights

A novel antibody identified the CD147 (basigin) molecule on cycling thymocytes. This molecule

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • A previously identified monoclonal antibody (mAb) targets a molecule on cycling thymocytes.
  • The precise identity and function of this molecule were not fully characterized.

Purpose of the Study:

  • To identify the molecule recognized by the mAb.
  • To investigate the role of this molecule in thymocyte development.

Main Methods:

  • Expression cloning was used to identify the target molecule.
  • Flow cytometry and antibody ligation assays were performed.

Main Results:

  • The molecule was identified as CD147 (basigin) in mice.
  • CD147 expression correlates with thymocyte cycling, independent of TCRbeta selection.
  • Ligation of CD147 on immature thymocytes inhibits their maturation.

Conclusions:

  • CD147 is a key regulator of immature thymocyte proliferation and development.
  • Targeting CD147 may offer a strategy to modulate T cell maturation.

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