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Cell response to AcrySof intraocular lenses in an Indian population

Abhay R Vasavada1, Lajja R Shastri, Shetal M Raj

  • 1Iladevi Cataract & IOL Research Centre, Ahmedabad, India. shailad1@sancharnet.in

Journal of Cataract and Refractive Surgery
|July 11, 2002
PubMed

Insights

Cell deposits on AcrySof intraocular lenses (IOLs) were evaluated in an Indian population. The study found a low incidence and severity of cell deposits, with all types disappearing within 12 months, indicating good biocompatibility.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Cell Biology

Background:

  • Cataract surgery is a common procedure worldwide.
  • Intraocular lenses (IOLs) are implanted to restore vision after cataract removal.
  • AcrySof IOLs are widely used, and their cytological response requires evaluation.

Purpose of the Study:

  • To assess the cytological response to AcrySof IOLs in an Indian population.
  • To quantify the incidence, progression, and severity of cell deposits on IOLs.
  • To determine the fate and resolution of these cell deposits post-surgery.

Main Methods:

  • A prospective clinical study involving 64 patients undergoing phacoemulsification and AcrySof IOL implantation.
  • Postoperative follow-up at 1 week and 1, 3, 6, 12, and 15 months.
  • Slit-lamp biomicroscopy with specular reflex to record cell deposit characteristics.

Main Results:

  • The highest incidence of small cell deposits was 18.7%, resolving within 6 months.
  • Large and giant cell deposits had a highest incidence of 23.4% and 6.2% respectively, resolving within 12-15 months.
  • No IOLs showed cell deposits at the final follow-up (mean 14 months).

Conclusions:

  • AcrySof IOLs demonstrated a low incidence and severity of cell deposits in the Indian population.
  • All observed cell types, including giant cells, resolved within one year.
  • These findings suggest good biocompatibility of AcrySof IOLs and appropriate surgical techniques.
Abstract

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