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BK virus-associated hemorrhagic cystitis in a Human Immunodeficiency Virus-infected patient

Dan H Barouch1, William C Faquin, Yiping Chen

  • 1Division of Infectious Diseases, Massachusetts General Hospital, and Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA. dan_barouch@hotmail.com

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 13, 2002
PubMed

Insights

BK virus-associated hemorrhagic cystitis is rare in HIV patients. This case study details a human immunodeficiency virus-infected patient with lymphoma who developed this condition, showing no response to cidofovir treatment.

Area of Science:

  • Urology
  • Virology
  • Oncology

Background:

  • BK virus-associated hemorrhagic cystitis (HC) is a known complication in bone marrow transplant recipients.
  • It is considered rare in other immunosuppressed populations, including those with human immunodeficiency virus (HIV).

Observation:

  • This report details a case of BK virus-associated HC in a patient with HIV and non-Hodgkin's lymphoma.
  • BK virus viruria was quantified using immunocytochemistry.

Findings:

  • The patient presented with BK virus-associated hemorrhagic cystitis, a condition typically rare in HIV-positive individuals.
  • Despite treatment with cidofovir, the patient showed no clinical improvement.

Implications:

  • This case highlights the potential for BK virus-associated HC to occur in HIV-infected patients with hematological malignancies.
  • It underscores the need for heightened clinical suspicion and potentially alternative treatment strategies for BK virus-associated HC in this patient group.

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