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Published on: September 12, 2019
[Infiltration of dendritic cells and lymphocytes in hepatocellular carcinoma tissue]
Xiaoyu Yin1, Mingde Lu, Lijian Liang
1Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. yinxy@gzsums.edu.cn
Insights
High infiltration of dendritic cells and lymphocytes in hepatocellular carcinoma (HCC) tissue indicates a better prognosis. Patients with significant immune cell presence showed delayed tumor recurrence and improved survival rates post-surgery.
Area of Science:
- Immunology
- Oncology
- Pathology
Context:
- Hepatocellular carcinoma (HCC) remains a significant global health challenge.
- Understanding the tumor microenvironment is crucial for improving HCC patient outcomes.
- Immune cell infiltration, specifically dendritic cells and lymphocytes, plays a role in anti-tumor immunity.
Purpose:
- To investigate the clinical significance of dendritic cells and lymphocytes infiltration in HCC tissue.
- To correlate immune cell infiltration levels with postoperative tumor recurrence and survival rates in HCC patients.
Summary:
- A study analyzed 44 HCC patients undergoing tumor resection.
- Immunohistochemical staining assessed dendritic cells and lymphocytes infiltration.
- Higher infiltration of both cell types correlated with significantly delayed recurrence and improved survival rates.
Impact:
- Dendritic cells and lymphocytes infiltration serves as an independent prognostic factor for HCC.
- This finding can inform prognostic assessments and therapeutic strategies for HCC.
- Highlights the importance of the immune microenvironment in HCC progression and patient prognosis.
Objective:
To explore the clinical significances of dendritic cells and lymphocytes infiltration in hepatocellular carcinoma (HCC) tissue.
Methods:
Clinicopathological data were collected from 44 patients with HCC who had under/gone curative tumor resection in our hospital. Immunohistochemical staining was used to detect the infiltration of dendritic cells in the tumor tissue, and lymphocytes infiltration was assessed simultaneously. The correlation between the infiltration of dendritic cells and lymphocytes and postoperative tumor recurrence and survival rate was analyzed.
Results:
Tumor recurrence was markedly late in patients with dendritic cells count >/= 20 and positive lymphocytes infiltration (group A, n = 17) as compared with those who did not meet both criteria simultaneously (group B, n = 27), with a median interval of 21.6 months for group A and 4.1 months for group B (U value = 105.5, P = 0.009). The 1-, 3-, 4-year survival rates were significantly greater in group A than in group B; they were 83.5% vs. 42.2%, 61.8% vs. 28.4% and 48.7% vs. 23.0%, respectively (Log rank = 7.68, P < 0.01).
Conclusion:
The infiltration of dendritic cells and lymphocytes in HCC tissue, as an independent prognostic factor, was closely related to postoperative prognosis.
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