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Primary cutaneous lymphoblastic lymphoma presenting in an 8-week old infant
Jacqueline K Trupiano1, Karen Bringelsen, Eric D Hsi
1Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA.
Insights
This study details a rare case of primary cutaneous lymphoblastic lymphoma (LBL) in an infant. The infant
Area of Science:
- Pediatric Oncology
- Dermatopathology
- Hematopathology
Background:
- Primary cutaneous lymphoblastic lymphoma (LBL) is a rare hematologic malignancy affecting the skin.
- Early diagnosis and characterization are crucial for appropriate management, especially in infants.
Observation:
- An 8-week-old infant presented with a rare form of primary cutaneous lymphoblastic lymphoma.
- Histopathology and flow cytometry revealed neoplastic cells with an unusual immunophenotype.
Findings:
- The lymphoblastic lymphoma cells expressed CD19, CD20, CD34, and surface immunoglobulin (sIg).
- This immunophenotype, described as "transitional pre-B-cell", indicates co-expression of immature (CD34) and mature (sIg) markers.
- The cells were negative for TdT and CD99.
Implications:
- This case represents one of the youngest reported instances of primary cutaneous LBL.
- The unusual immunophenotype expands the understanding of precursor B-cell LBL spectrum.
- Further research into such rare pediatric cutaneous lymphomas is warranted.
Background:
We report a case of primary cutaneous lymphoblastic lymphoma (LBL) presenting in an 8-week-old infant.
Methods:
Histopathology and flow cytometric analysis confirmed the diagnosis of a lymphoblastic lymphoma. The cells expressed CD19, CD20, CD34 and surface immunoglobulin (sIg).
Results:
The cells were negative for TdT and CD99. This unusual immunophenotype has been described as "transitional pre-B-cell", in that the cells express both immature markers (CD34) and mature markers (sIg).
Conclusions:
To our knowledge, only five other cases of sIg positive precursor B-cell LBL have been reported in the literature. This may represent the youngest reported case of primary cutaneous LBL, occurring at 8weeks of age.