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Hepatic lymphangiomatosis in a young dog
Tetsushi Yamagami1, Naoyuki Takemura, Tsukimi Washizu
1Marupi-lifetech Co. Ltd., Ikeda, Osaka, Japan.
Insights
A rare canine liver condition, hepatic lymphangiomatosis, was diagnosed in a cocker spaniel presenting with enlarged liver and fluid accumulation. This vascular anomaly involves abnormal blood vessel growth within the liver tissue.
Area of Science:
- Veterinary Pathology
- Canine Hepatology
- Vascular Anomalies
Background:
- Hepatomegaly and ascites are significant clinical signs in dogs, prompting further investigation into underlying liver pathology.
- Vascular anomalies of the liver can present with non-specific clinical and ultrasonographic findings, making definitive diagnosis challenging.
Observation:
- A 9-month-old American cocker spaniel exhibited hepatomegaly and ascites.
- Liver ultrasonography revealed congestion, increased echogenicity, and hyperechoic nodules.
- Histopathology demonstrated diffuse, ill-defined vascular proliferation with atypical endothelial cells.
Findings:
- Immunohistochemistry confirmed the endothelial cells expressed factor VIII related antigen.
- The findings were consistent with a diagnosis of hepatic lymphangiomatosis.
- This condition involves abnormal lymphatic vessel proliferation within the liver.
Implications:
- This case highlights the importance of considering vascular anomalies in canine liver disease.
- Accurate diagnosis of hepatic lymphangiomatosis is crucial for appropriate patient management.
- Further research into the pathogenesis and treatment of canine hepatic lymphangiomatosis is warranted.
Abstract:
A 9-month-old intact male American cocker spaniel was referred because of hepatomegaly and ascites. Ultrasonographic evaluation of the liver revealed congestion and increased parenchymal echogenicity with focal and more hyperechoic nodules. Histopathology of the hepatic lesion revealed diffuse, ill-defined vascular proliferation. A single layer of endothelial cells, which showed signs of minimal cellular atypia, lined the irregular vessels. On immunohistochemistry, the proliferative endothelial cells lining the irregular vessels were positive for an antiserum to factor VIII related antigen. Based on these findings, the dog was diagnosed with hepatic lymphangiomatosis.