Related Experiment Video
Updated: Aug 10, 2026

Teratoma Generation in the Testis Capsule
Published on: November 7, 2011
[Leydig cell tumor of the testis presenting male infertility: a case report]
Toyofumi Abe1, Natsuki Takaha, Akira Tsujimura
1Department of Urology, Osaka University Graduate School of Medicine.
Insights
A testicular Leydig cell tumor caused male infertility and scrotal swelling in a 33-year-old man. Surgical removal of the tumor normalized hormonal profiles, aiding in understanding Leydig cell tumor effects.
Area of Science:
- Endocrinology
- Urology
- Oncology
Background:
- Leydig cell tumors are rare testicular neoplasms.
- They can present with symptoms of infertility or hormonal imbalances.
- Diagnosis often involves imaging and histological examination.
Observation:
- A 33-year-old male presented with infertility and left scrotal swelling.
- Initial diagnosis suggested a left testicular tumor.
- Left high orchiectomy was performed.
Findings:
- Histological examination confirmed the testicular mass as a Leydig cell tumor.
- The patient's hormonal profile was assessed before and after surgery.
- A review of 55 previously reported Japanese cases provided comparative data.
Implications:
- This case highlights the association between Leydig cell tumors and male infertility.
- Understanding the hormonal profile is crucial for managing these tumors.
- Further data on Leydig cell tumors can improve diagnostic and therapeutic strategies.
Abstract:
A 33-year-old male was referred to our hospital for male infertility with painless swelling of the left scrotal content. Left high orchiectomy was performed under the diagnosis of left testicular tumor. Histologically, this testicular mass was a Leydig cell tumor. We reviewed 55 cases of Leydig cell tumor of the testis previously reported in Japan, and reported the hormonal profile in our case before and after surgery.
Related Concept Videos
Spermatogenesis
Sex-linked Disorders
Testes: Gross Anatomy
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
Testes: Histology
The spermatogenic cells, responsible for producing sperm, are...
Infertility in Males
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

