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Published on: July 31, 2016
[A case of primary hepatic lymphoma successfully treated by THP-COP therapy]
Katsuhiko Takauchi1, Hidekazu Kono, Tatsuya Ito
1Department of Internal Medicine, Sera Chuo Public Hospital.
Insights
A rare case of primary hepatic lymphoma (diffuse large B cell type) in a 65-year-old woman achieved complete remission with chemotherapy. This conservative treatment approach offers valuable insights for managing this infrequent liver cancer.
Area of Science:
- Hepatology
- Oncology
- Hematology
Background:
- Primary hepatic lymphoma is a rare malignancy, often lacking established treatment protocols.
- Surgical resection is a common treatment modality in Japan for primary hepatic lymphoma.
- This study presents a case of a rare liver cancer in a 65-year-old woman presenting with epigastralgia.
Observation:
- Abdominal ultrasonography and CT scans identified a liver tumor in the umbilical portion.
- Needle biopsy confirmed the tumor as non-Hodgkin's lymphoma, specifically diffuse large B-cell type.
Findings:
- The patient received the THP-COP chemotherapy protocol.
- Complete remission was achieved after only three cycles of treatment.
- Histology and histoimmunology confirmed the diagnosis and treatment response.
Implications:
- A conservative chemotherapy approach can be effective for primary hepatic lymphoma.
- This case contributes to the discussion on optimal treatment strategies for rare liver cancers.
- Further research is needed to establish standardized treatment guidelines for primary hepatic lymphoma.
Abstract:
A 65-year-old woman was admitted due to epigastralgia. The presence of a tumor mass in the umbilical portion of the liver was recognized by abdominal ultrasonography and computed tomography scan. Needle biopsy of the tumor showed non Hodgkin's lymphoma (diffuse large B cell type) by histology and histoimmunology. She was treated by the THP-COP protocol, and complete remission was achieved after the third cycle. Primary hepatic lymphoma is so infrequent that standard treatments are not established yet. Most cases of primary hepatic lymphoma are treated by surgical resection in Japan; however our conservative approach to remission is considered as very helpful for discussing how to treat primary hepatic lymphoma.
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