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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Natural killer cell-type body cavity lymphoma following chronic active Epstein-Barr virus infection

Masao Ogata1, Tomoyuki Imamura, Syunji Mizunoe

  • 1Second Department of Internal Medicine, Oita Medical University, Hasama-machi, Oita, Japan. mogata@oita-med.ac.jp

American Journal of Hematology
|May 16, 2003
PubMed

Insights

A rare case of natural killer cell lymphoma developed after chronic active Epstein-Barr virus (CAEBV) infection. This HHV-8 negative lymphoma responded well to combination chemotherapy.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Chronic active Epstein-Barr virus (CAEBV) infection is a rare condition.
  • Body cavity lymphoma (BCL) is an uncommon non-Hodgkin lymphoma.

Observation:

  • A 69-year-old female presented with persistent fever and was diagnosed with CAEBV infection.
  • She subsequently developed natural killer (NK) cell-type BCL.
  • Lymphocytes in pleural effusion were abnormal (CD2+, CD7+, CD30+, CD56+, CD3-, CD4-).

Findings:

  • Clonal proliferation of EBV-infected cells was confirmed in pleural effusion.
  • T cell receptor gene rearrangement was not detected.
  • Human herpesvirus type-8 (HHV-8) DNA was absent.
  • High EBV DNA load in plasma confirmed CAEBV infection, despite normal antibody titers.

Implications:

  • This case highlights a unique presentation of lymphoma following CAEBV infection.
  • It demonstrates the development of HHV-8-negative BCL.
  • Combination chemotherapy proved effective for this specific lymphoma type.

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