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A case of perineurioma with prominent myxoid changes
1Servico de Anatomia Patológica. Hospital Civil de Bilbao, Spain.
Archives D'Anatomie Et De Cytologie Pathologiques
|January 1, 1992
Insights
This study presents a rare myxoid perineurioma, a skin tumor. Diagnosis was confirmed through immunohistochemistry, highlighting its unique cellular characteristics.
Area of Science:
- Dermatopathology
- Oncology
- Soft Tissue Tumors
Background:
- Perineuriomas are rare tumors arising from the peripheral nerve sheath.
- Myxoid changes can sometimes be a prominent feature, complicating diagnosis.
- Understanding the immunohistochemical profile is crucial for accurate classification.
Observation:
- A case of a 41-year-old woman with a small back skin nodule is described.
- Microscopic examination revealed a tumor with subtle cellular whorls in a myxoid stroma.
- The lesion presented as a superficial cutaneous nodule.
Findings:
- Immunohistochemistry demonstrated positivity for epithelial membrane antigen (EMA).
- The tumor cells were negative for S-100 protein, common leukocyte antigen (CLA), vimentin, and AE1-AE3 cytokeratin.
- These findings support a diagnosis of perineurioma with significant myxoid differentiation.
Implications:
- This case expands the understanding of perineurioma variants.
- Accurate diagnosis is essential for appropriate patient management and prognosis.
- Highlights the importance of EMA in differentiating perineuriomas from other soft tissue tumors.
Abstract:
A perineurioma with prominent myxoid changes is presented. The patient, a 41 year-old woman, presented with a small skin nodule on her back. Light microscopy revealed subtle cellular whorls within a myxoid background. Immunohistochemistry showed epithelial membrane antigen positivity. In contrast, S-100 protein, common leukocyte antigen, vimentin and AE1-AE3 cytokeratin were negative.