[A case of Bufferin induced acute interstitial nephritis--analysis of immune cells and cytokine]

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Updated: Jul 28, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

M Okada1, K Yoshioka, S Isokawa

  • 1Department of Pediatrics, Kinki University School of Medicine.

Nihon Jinzo Gakkai Shi
|November 1, 1992
PubMed

Insights

This case report details acute interstitial nephritis in a teenager caused by Bufferin. The findings suggest cell-mediated immune responses contribute to drug-induced kidney injury.

Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Acute interstitial nephritis (AIN) is a kidney disease often caused by medications.
  • Identifying the causative agent is crucial for effective treatment and management.

Observation:

  • A 15-year-old female presented with fever and impaired renal function, including elevated BUN and creatinine.
  • Renal biopsy revealed interstitial edema, inflammatory cell infiltration (T cells, monocytes/macrophages), and minor glomerular changes.
  • Interstitial cells expressed interleukin-1 (IL-1) and tumor necrosis factor (TNF).

Findings:

  • Bufferin tested positive in a lymphocyte stimulation test, indicating a potential drug hypersensitivity.
  • The patient's presentation and biopsy results were consistent with drug-induced AIN.
  • Evidence suggests a cell-mediated immune mechanism underlying the observed kidney injury.

Implications:

  • This case highlights Bufferin as a potential cause of AIN.
  • The findings support the role of T-cell mediated immunity in drug-induced AIN.
  • Further research into immune mechanisms of drug-induced kidney injury is warranted.

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