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Epstein-Barr virus in Hodgkin's disease from patients with human immunodeficiency virus infection

C A Moran1, S Tuur, P Angritt

  • 1Department of Infectious, Armed Forces Institute of Pathology, Washington, DC 20306-6000.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|January 1, 1992
PubMed

Insights

Human immunodeficiency virus (HIV) positive patients show a higher prevalence of Epstein-Barr virus (EBV) in Hodgkin's disease. This suggests a stronger link between EBV and Hodgkin's disease in individuals with HIV.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Hodgkin's disease is a cancer of the lymphatic system.
  • Epstein-Barr virus (EBV) is a common herpesvirus.
  • Human immunodeficiency virus (HIV) compromises the immune system.

Purpose of the Study:

  • To investigate the association between Epstein-Barr virus (EBV) and Hodgkin's disease in HIV-positive patients.
  • To compare EBV prevalence in Hodgkin's disease between HIV-positive and HIV-negative individuals.

Main Methods:

  • Polymerase chain reaction (PCR) was employed to detect EBV DNA.
  • Specimens from 10 HIV-positive Hodgkin's disease patients were analyzed.
  • A control group of 57 HIV-negative Hodgkin's disease patients was included.

Main Results:

  • Epstein-Barr virus (EBV) DNA was detected in 80% (8/10) of HIV-positive Hodgkin's disease specimens.
  • EBV was found in 40.35% (23/57) of HIV-negative Hodgkin's disease specimens.
  • A significantly higher prevalence of EBV was observed in the HIV-positive group.

Conclusions:

  • Epstein-Barr virus (EBV) infection shows a closer association with Hodgkin's disease in patients with HIV infection.
  • Findings suggest a potential synergistic role of HIV and EBV in Hodgkin's disease pathogenesis.
  • Further research is warranted to elucidate the mechanisms underlying this association.

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