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Published on: August 15, 2019
[Splenic lymphoma of Ki-1 positive B-cell type treated with CHOP]
T Terashima1, K Tominaga, M Tuji
1Department of Internal Medicine, Social Insurance Saitama Chuo Hospital.
Insights
A rare B-cell Ki-1 lymphoma case presenting with lymphadenopathy and splenomegaly achieved complete remission with CHOP chemotherapy. This study discusses the pathological and clinical features of this specific lymphoma subtype.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Ki-1 lymphoma, a rare subtype, presents diagnostic challenges.
- B-cell lymphomas require precise pathological identification for effective treatment.
Observation:
- A 75-year-old male presented with supraclavicular and cervical lymphadenopathy, and splenomegaly.
- CT scan revealed paraaortic lymphadenopathy and splenic lesions.
- Biopsy confirmed Ki-1 lymphoma with characteristic large cells positive for IgM, lambda, CD20, and CD30 (Ki-1).
Findings:
- The spleen was suspected as the primary lymphoma site based on imaging.
- The patient achieved complete remission following systemic chemotherapy using the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone).
Implications:
- This case highlights the importance of thorough pathological and radiological evaluation for diagnosing Ki-1 lymphoma.
- Successful treatment with CHOP chemotherapy suggests its efficacy in managing this B-cell lymphoma variant.
- Further research into the specific characteristics and optimal management of B-cell Ki-1 lymphoma is warranted.
Abstract:
A 75-year old man was admitted to our hospital by complaining of his left supraclavicular lymphadenopathy. Physical examination also revealed splenomegaly and cervical lymphadenopathy. An abdominal CT scan showed paraaortic lymphadenopathy and splenomegaly with multiple low density area. A pathological diagnosis of Ki-1 lymphoma was made by the biopsied supraclavicular lymph node because the node consists of large cells with clear cytoplasms and conspicuous nucleoli and large cells were positive for IgM, lambda, CD20 and CD30 (Ki-1). The primary lesion of lymphoma was suspected to be spleen because of the radiological finding of the spleen. The patient responded to systemic chemotherapy (CHOP) with complete remission. Pathological and clinical characteristics of this B-cell Ki-1 lymphoma were discussed.
