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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Immunophenotypical characterization of inflammatory cellular infiltrates in tinea

J Brasch1, W Sterry

  • 1Department of Dermatology, University of Kiel, Germany.

Acta Dermato-Venereologica
|September 1, 1992
PubMed

Insights

Acute tinea infections involve specific immune cells like T helper lymphocytes and macrophages, with few B cells. This study highlights the role of Langerhans cells and macrophages in the skin

Area of Science:

  • Dermatology
  • Immunology
  • Mycology

Background:

  • The pathogenesis of acute tinea infections remains incompletely understood.
  • Inflammatory cellular infiltrates play a key role in skin infections.

Purpose of the Study:

  • To analyze the inflammatory cellular infiltrates in acute tinea.
  • To elucidate the pathogenetic pathways of acute tinea.

Main Methods:

  • Lesional punch biopsies were obtained from patients with acute tinea.
  • Immunophenotypization of inflammatory cells was performed using monoclonal antibodies.
  • Quantification of T cells, B cells, macrophages, and activation markers in dermal and epidermal layers.

Main Results:

  • Dermal infiltrates were predominantly T helper lymphocytes (memory type), macrophages, and Langerhans cells, with minimal B cells.
  • A high proportion of inflammatory cells expressed activation markers.
  • Epidermal accumulations of Langerhans cells and LeuM5+ dendritic macrophages were observed near fungal elements.

Conclusions:

  • Acute tinea exhibits a distinct inflammatory infiltrate, primarily composed of T helper lymphocytes and macrophages.
  • The findings suggest a potential role for Langerhans cells and LeuM5+ macrophages in acute tinea pathogenesis.
  • Acute tinea may serve as a model for studying the functional interplay between Langerhans cells and macrophages in dermatoses.

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