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[Malignant lymphoma and leukemia concepts in new WHO classification]

Masahiro Kikuchi1

  • 1Department of Pathology, School of Medicine, Fukuoka University, Fukuoka 814-0180.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|September 19, 2003
PubMed

Insights

The updated WHO classification integrates lymphoma, myeloid, and histiocytic/dendritic neoplasms based on morphology, genetics, and clinical features. This revised system enhances the classification of lymphoid and myeloid malignancies for better diagnosis.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Context:

  • The REAL classification of lymphoma has been updated and expanded.
  • The classification now includes myeloid, mast cell, and histiocytic/dendritic neoplasms.
  • Lymphoid malignancies are now grouped into B cell, T/NK cell, and Hodgkin lymphoma categories.

Purpose:

  • To present the new World Health Organization (WHO) classification of hematopoietic and lymphoid neoplasms.
  • To define distinct diseases using morphology, immunophenotype, genetic features, and clinical syndromes.
  • To postulate the cell origin for accurate disease categorization.

Summary:

  • The new WHO classification expands upon the REAL classification principles for lymphomas.
  • It incorporates myeloid, mast cell, and histiocytic/dendritic neoplasms.
  • Diseases are defined by a combination of morphology, immunophenotype, genetics, and clinical presentation, with cell origin postulated.
  • Lymphoid malignancies are categorized into B cell, T/NK cell, and Hodgkin lymphoma.
  • Myeloid neoplasms are classified into four main groups: chronic myeloproliferative diseases, myelodysplastic/myeloproliferative diseases, myelodysplastic diseases, and acute myeloid leukemia.

Impact:

  • Provides a standardized framework for diagnosing and classifying hematopoietic and lymphoid neoplasms.
  • Facilitates clearer communication and research among hematologists and oncologists.
  • Aids in understanding the distinct biological characteristics and origins of these diseases.

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