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Published on: January 28, 2014
Acute lymphoblastic leukemia of Burkitt type (L3) with a (14;18) and an atypical (8;22) translocation
S R Smith1, N Bown, J P Wallis
1Department of Haematology, Freeman Hospital, Newcastle upon Tyne, England.
Insights
This study reports a rare case of Burkitt-type acute lymphoblastic leukemia (ALL) in a 67-year-old man. The patient presented with night sweats and tumor lysis syndrome, alongside a unique genetic profile involving novel translocations.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Burkitt-type acute lymphoblastic leukemia (ALL) is an aggressive B-cell malignancy.
- Typical genetic hallmarks include the MYC translocation, often t(8;14).
Observation:
- A 67-year-old male patient presented with night sweats and tumor lysis syndrome.
- Histologic and immunophenotypic analyses confirmed Burkitt-type ALL.
Findings:
- Cytogenetic analysis revealed a novel karyotype.
- This included a t(14;18) translocation and an atypical t(8;22) translocation.
Implications:
- This case highlights the genetic diversity within Burkitt-type ALL.
- The novel karyotype may influence treatment strategies and prognosis.
- Further research is needed to understand the impact of these specific translocations.
Abstract:
A 67-year-old man had night sweats, tumor lysis syndrome, and typical histologic and immunophenotypic features of Burkitt-type acute lymphoblastic leukemia (ALL). Cytogenetic analysis showed a previously unreported karyotype, a combination of a (14;18) and an atypical (8;22) translocation.
