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Cerebrospinal fluid T cell receptor gamma/delta+ lymphocyte subsets in patient with AIDS-dementia complex
O Perrella1, M Soscia, C Iaccarino
1III Department D, Cotugno Hospital for Infectious Diseases, Napoli, Italy.
Insights
T-cell receptor (TCR) gamma/delta lymphocytes were studied in patients with AIDS dementia complex (ADC). Researchers found these T cells in cerebrospinal fluid of ADC patients, but no significant difference compared to controls.
Area of Science:
- Immunology
- Neuroscience
- Virology
Background:
- A subset of peripheral T cells expresses T-cell receptor (TcR) gamma/delta.
- The physiological function of TcR gamma/delta lymphocytes remains largely unknown.
- AIDS dementia complex (ADC) is a neurological complication associated with HIV infection.
Purpose of the Study:
- To characterize TcR gamma/delta lymphocytes and their subset (TcS delta 1+) in the peripheral blood and cerebrospinal fluid (CSF) of ADC patients.
- To compare the presence of these cells in ADC patients versus individuals with other non-inflammatory neurological diseases (OND).
Main Methods:
- Utilized two monoclonal antibodies for characterization.
- Analyzed peripheral blood and CSF samples.
- Recruited 30 patients with ADC and 20 individuals with OND.
Main Results:
- TcR gamma/delta cells were detected in the cerebrospinal fluid of ADC patients.
- No statistically significant difference was observed in the presence of TcR gamma/delta cells between ADC patients and the OND control group.
Conclusions:
- TcR gamma/delta lymphocytes are present in the CSF of individuals with AIDS dementia complex.
- The study did not find a differential distribution of TcR gamma/delta cells in CSF that distinguishes ADC from other neurological conditions.
Abstract:
A subset of peripheral T cells, whose physiological function is little known, expresses a distinct CD3-associated receptor composed of gamma and delta chains. We used two monoclonal antibodies to characterize the TcR gamma/delta lymphocytes (TcR delta 1+) and their fraction (TcS delta 1+) in peripheral blood and cerebrospinal fluid of patients affected by AIDS dementia complex (ADC). Thirty patients with ADC and a control group of twenty individuals with other non-inflammatory neurological diseases (OND) were recruited. Our results demonstrate that the TcR gamma/delta cells were also present in cerebrospinal fluid of ADC patients, but we did not find any statistical difference between the two groups.