Related Experiment Video

Updated: Sep 3, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

Humoral and cellular immunologic study of cerebrospinal fluid in a patient with Behçet encephalitis

P J Jongen1, H E Daelmans, B Bruneel

  • 1Department of Neurology, University Hospital Nijmegen, The Netherlands.

Archives of Neurology
|October 1, 1992
PubMed

Insights

Neuro-Behçet syndrome involves immune system activation in the brain, with immunoglobulin and T-cell changes during encephalitis. Treatment normalized these immune markers, suggesting their role in Behçet encephalitis.

Area of Science:

  • Neuroimmunology
  • Neurology
  • Rheumatology

Background:

  • Neuro-Behçet syndrome is a rare condition affecting the central nervous system.
  • Understanding its immunopathogenesis is crucial for effective treatment.

Observation:

  • Serial cerebrospinal fluid (CSF) analysis was performed in a patient with neuro-Behçet syndrome.
  • Measurements included immunoglobulins (Ig), complement components (C3, C4), immune complexes, and lymphocyte subsets.
  • Analysis was conducted before and after immunosuppressive therapy.

Findings:

  • Active encephalitis showed intrathecal production of IgM, IgG, IgA, and C3, with elevated CSF C3 and C4.
  • Immune complexes were present in CSF but not peripheral blood.
  • Increased CSF CD8+ T-cells and peripheral blood CD3+/CD8+ T-cells were observed.
  • Immunosuppressive treatment normalized these CSF humoral and cellular abnormalities.

Implications:

  • Intrathecal immunoglobulin and C3 production, immune complexes, and CD8+ T-cells likely contribute to Behçet encephalitis.
  • These findings highlight key immune mechanisms in neuro-Behçet syndrome.
  • Targeting these pathways may offer therapeutic strategies for Behçet encephalitis.

More Related Videos

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis08:20

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis

Published on: June 2, 2022

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...