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Chronic neutrophilic leukemia (CNL) with karyotypic abnormalities associated with plasma cell dyscrasia: a case
L Masini1, C Salvarani, P Macchioni
1I Divisione Medica, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Insights
This report details a rare case of chronic neutrophilic leukemia (CNL) with monoclonal gammopathy. The study identified a unique karyotypic abnormality, Y chromosome loss, in the patient
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm.
- Monoclonal gammopathy of uncertain significance (MGUS) can occur in hematologic disorders.
Observation:
- A case of CNL associated with MGUS (Type IgGk) is presented.
- Karyotypic analysis of bone marrow revealed a Y chromosome loss (45, X0).
Findings:
- The karyotypic abnormality (Y loss) and paraproteinemia (MGUS) were observed concurrently in this CNL case.
- Philadelphia chromosome-positive chronic myeloid leukemia (CML) was excluded.
Implications:
- This case expands the understanding of CNL's genetic landscape.
- Highlights the importance of comprehensive cytogenetic and immunochemical analysis in CNL.
Abstract:
A case of chronic neutrophilic leukemia (CNL), a rare myeloproliferative syndrome associated with monoclonal gammopathy of uncertain significance (MGUS-Type IgGk), is reported. Karyotypic study, carried out on bone marrow, excluded Philadelphia-pos. chronic myeloid leukemia (CML) and showed Y loss (45 XO). Only a few cases of CNL with paraproteinemia have been reported, but no case of associated karyotypic abnormalities and paraproteinemia has so far been described.
