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Interinstitutional pathology consultations. A reassessment
Michele M Weir1, E Jan, Terence J Colgan
1Department of Pathology, London Health Sciences Centre, University of Western Ontario, London, Canada.
Insights
Interinstitutional pathology consultations (IPCs) can reveal diagnostic discrepancies. While most IPCs are concordant, a small percentage significantly impact patient management, highlighting the value of these consultations.
Area of Science:
- Pathology
- Medical Diagnostics
- Clinical Decision Making
Background:
- Interinstitutional pathology consultations (IPCs) are crucial for verifying diagnoses.
- Assessing the clinical impact of IPCs is essential for optimizing diagnostic workflows.
Purpose of the Study:
- To retrospectively evaluate the clinical impact of 1,000 randomly selected IPCs.
- To determine the frequency and reasons for diagnostic discrepancies identified through IPCs.
Main Methods:
- Retrospective review of 1,000 randomly selected IPCs, including all patient specimens.
- Classification of IPCs as concordant or discordant, with discordant cases further analyzed for clinical impact and reasons for discrepancy.
Main Results:
- 92.3% of IPCs were concordant; 6.8% were discordant.
- Of discordant IPCs, 37 had a clinical impact, often due to interpretation differences (e.g., overdiagnosis, underdiagnosis, or stage changes).
- Reasons for discordance included interpretation differences, additional sectioning, ancillary testing, and clerical errors.
Conclusions:
- IPCs can identify significant diagnostic discrepancies that influence patient management.
- The clinical impact of IPCs varies by body site, suggesting potential for targeted consultation strategies.
- While mandatory IPCs ensure discrepancy identification, alternative strategies like targeted IPCs warrant further investigation.
Abstract:
We retrospectively determined the clinical impact of 1,000 randomly selected interinstitutional pathology consultations (IPCs). An IPC included all specimens from the patient. IPCs were classified as concordant or discordant with the original diagnosis. Discordant IPCs were classified as having a clinical impact or no impact. Discordant IPCs owing to interpretation differences were subclassified further. The IPCs included 1,522 specimens (1,204 histology, 318 cytology); 923 (92.3%) were concordant, 9 (0.9%) indeterminate, and 68 (6.8%) discordant (clinical impact, 37; no impact, 31). Reasons for discordant IPCs were interpretation differences, 45; additional sectioning, 7; ancillary testing, 1; clerical error, 5; or a combination, 10. Reasons for 26 discordant IPCs with clinical impact owing to interpretation differences were overdiagnosis, 11; tumor subtype change, 4; stage change, 4; underdiagnosis, 3; resection margin status change, 2; undergrading, 1; and understaging with resection margin status change, 1. IPC may identify diagnostic discrepancies that impact management for some patients. The prevalence of a clinical impact of IPC on management varies according to body site. Mandatory IPC does ensure identification of clinically significant diagnostic discrepancies; targeted IPC by body site or specimen type may represent an alternative strategy after further data accumulation. Discordant IPCs may be due to factors other than interpretation difference.
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