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Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: two case reports

H L Ee1, G Yosipovitch, R Chan

  • 1National Skin Centre, 1 Mandalay Road, Singapore 308205, Republic of Singapore. ee_melvin@hotmail.com

The British Journal of Dermatology
|September 27, 2003
PubMed

Insights

Vulvitis circumscripta plasmacellularis (VCP), a rare condition, often resists treatment. Topical imiquimod effectively resolved VCP lesions in two patients resistant to other therapies.

Area of Science:

  • Dermatology
  • Gynecologic Dermatology
  • Vulvar Pathology

Background:

  • Vulvitis circumscripta plasmacellularis (VCP) is a rare vulvar condition.
  • VCP is known for its resistance to conventional treatments.
  • Previous treatments like intralesional interferon-alpha have shown efficacy but carry risks such as myelosuppression.

Observation:

  • Two cases of VCP are presented.
  • Lesions in both patients were refractory to antibiotics, topical corticosteroids, and oral corticosteroids.
  • Topical imiquimod was used as a treatment trial for these resistant cases.

Findings:

  • Topical imiquimod treatment led to complete resolution of VCP lesions in both reported cases.
  • This suggests imiquimod's potential efficacy in managing recalcitrant VCP.
  • The mechanism may involve imiquimod's ability to induce interferon-alpha production.

Implications:

  • Topical imiquimod represents a promising therapeutic option for vulvitis circumscripta plasmacellularis.
  • It offers an alternative for patients with treatment-resistant VCP.
  • Further research into imiquimod for VCP is warranted to confirm these findings and assess long-term outcomes.

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