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Unilateral uveitis induced by a nonionic iodinated contrast agent

Eveline Welzl-Hinterkörner1, Mark Haefner, Bernard Mengiardi

  • 1Departments of Ophthalmology, City Hospital Triemli, Zurich, Switzerland. eveline.welzl@triemli.stzh.ch

American Journal of Ophthalmology
|November 5, 2003
PubMed

Insights

Recurrent uveitis occurred in a lymphoma patient after contrast-enhanced computed tomography (CT) scans using iopamidol. This suggests iopamidol may trigger uveitis, potentially due to immune responses and prior radiation damage.

Area of Science:

  • Ophthalmology
  • Radiology
  • Oncology

Background:

  • A 44-year-old male with Stage I B mixed-cellularity Hodgkin lymphoma in remission.
  • Patient received chemotherapy and radiotherapy for lymphoma.
  • Underwent regular contrast-enhanced computed tomography (CT) scans for monitoring.

Observation:

  • The patient experienced recurrent unilateral anterior uveitis, vitritis, and retinal bleedings.
  • These ocular symptoms consistently appeared within hours after receiving intravenous iopamidol for CT scans.
  • Symptoms resolved within a week with topical corticosteroid treatment.

Findings:

  • Recurrent unilateral uveitis was observed following iopamidol-enhanced CT scans.
  • The contrast agent iopamidol was administered intravenously (150 ml).
  • The patient had a history of treated lymphoma.

Implications:

  • Iopamidol may induce uveitis in susceptible individuals.
  • A potential mechanism involves the interplay of immunologic responses and pre-existing vascular damage from radiation therapy.
  • Highlights the importance of considering contrast agent-induced ocular inflammation in patients with a history of cancer treatment.
Abstract

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