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Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections
Published on: November 14, 2016
Anaplastic large cell Ki-1 lymphoma in the central nervous system: report of an autopsy case
M Miyazono1, T Iwaki, J Tateishi
1Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Insights
This study reports a rare case of Ki-1-positive lymphoma in the central nervous system (CNS). The findings highlight the importance of identifying this specific lymphoma subtype in brain lesions.
Area of Science:
- Neuropathology
- Hematopathology
- Oncology
Background:
- Non-Hodgkin's lymphomas are a diverse group of lymphoid malignancies.
- Ki-1-positive lymphomas, characterized by the Ki-1 antigen (CD30), are a recognized subtype.
- Central nervous system (CNS) lymphomas can present with varied histopathological features.
Observation:
- A 45-year-old immunocompetent male presented with multiple brain lesions.
- Histological examination revealed diffuse lymphoid cell infiltrates with polymorphism and multinucleated giant cells.
- Immunolabeling confirmed B cell lineage and the presence of Ki-1 antigen (CD30).
Findings:
- The case represents a rare instance of Ki-1-positive lymphoma originating within the CNS.
- The histological and immunophenotypical profile aligns with previously described Ki-1-positive lymphomas.
- Review of prior cases provides context for this CNS manifestation.
Implications:
- Accurate diagnosis of CNS lymphomas is crucial for appropriate treatment strategies.
- Recognition of Ki-1-positive lymphoma in the CNS expands the understanding of its potential sites of occurrence.
- This case contributes to the literature on rare CNS malignancies and their classification.
Abstract:
A 45-year old immunocompetent man presented with multiple lesions in the brain. A histological examination of the tumors showed a diffuse infiltrate of lymphoid cells with cellular polymorphism and of multinucleated giant cells. These cells were immunolabeled with antibodies against B cell lineage and with a monoclonal antibody, Ber-H2 (CD30), which showed the presence of Ki-1 antigen. Recently, among systemic non-Hodgkin's lymphomas, attention has been given to Ki-1-positive lymphomas, which have been incorporated in the up-dated Kiel classification. We report here a case of Ki-1-positive lymphoma arising in the CNS and review previously reported cases.