Related Experiment Video

Updated: Aug 10, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

FcgammaRIIB is differentially expressed during B cell maturation and in B-cell lymphomas

Sophie Camilleri-Broët1, Lydie Cassard, Philippe Broët

  • 1Service d'Anatomie Pathologique, Hôtel Dieu, AP-HP, Université Paris VI, Paris, France. sophie.camilleri-broet@htd.ap-hop-paris.fr

British Journal of Haematology
|December 17, 2003
PubMed

Insights

FcgammaRIIB expression is found in various B-cell lymphomas, challenging its role in germinal center selection. FcgammaRIIB expression in diffuse large B-cell lymphoma (DLBCL) indicates a poor prognosis.

Area of Science:

  • Immunology
  • Hematopathology
  • Molecular Biology

Background:

  • FcgammaRIIB (Fc receptor like 2) is a low-affinity receptor for immunoglobulin G (IgG).
  • It is hypothesized to induce B-cell apoptosis in germinal centers (GC) through immune complex interactions, mediating negative selection.
  • The precise role and expression patterns of FcgammaRIIB in B-cell malignancies remain incompletely understood.

Purpose of the Study:

  • To investigate the expression of FcgammaRIIB in reactive lymphoid tissues and various B-cell lymphomas.
  • To determine the correlation between FcgammaRIIB expression and clinicopathological features, particularly in diffuse large B-cell lymphoma (DLBCL).
  • To evaluate the prognostic significance of FcgammaRIIB expression in DLBCL.

Main Methods:

  • Immunohistochemistry was employed to assess FcgammaRIIB expression in 22 reactive lymphoid tissues and 112 B-cell lymphomas.
  • Gene expression profiling data from Lymphochip microarrays were re-analyzed for FcgammaRIIB expression in DLBCL subgroups.
  • Statistical analyses, including univariate and multivariate analyses with the International Prognostic Indicator (IPI), were performed.

Main Results:

  • FcgammaRIIB was expressed in pre-GC mantle cells, marginal zone cells, B chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphomas.
  • FcgammaRIIB was notably absent in germinal centers but detected in 52% of follicular lymphomas and 20% of DLBCLs.
  • In DLBCL, FcgammaRIIB expression correlated with transformation and was associated with an adverse prognosis, particularly in the activated B-cell-like subgroup.

Conclusions:

  • The findings challenge the proposed role of FcgammaRIIB in B-cell selection within germinal centers.
  • FcgammaRIIB expression in DLBCL is linked to transformation and serves as a significant adverse prognostic marker.
  • FcgammaRIIB warrants further investigation as a potential therapeutic target or prognostic biomarker in DLBCL.

More Related Videos

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish08:32

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

Flow Cytometric Characterization of Murine B Cell Development08:25

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...