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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Epstein-Barr virus-induced transformation of cutaneous plasmacytoma into CD30+ diffuse large B-cell lymphoma
1Department of Pathology, Scott & White Memorial Hospital, The Texas A&M University System Health Science Center, College of Medicine, Temple, TX 76508, USA. ldonner@swmail.sw.org
Insights
A rare case shows cutaneous plasmacytoma transforming into CD30+ large B-cell lymphoma. Both distinct cell types were positive for Epstein-Barr virus RNAs, but EBV-LMP1 expression differed.
Area of Science:
- Hematology
- Oncology
- Dermatopathology
Background:
- Cutaneous plasmacytomas are rare plasma cell neoplasms.
- Transformation into aggressive lymphomas is infrequently reported.
Observation:
- A unique case of cutaneous plasmacytoma evolving into CD30+ large B-cell lymphoma is presented.
- Distinct immunophenotypes were observed for plasma cells (CD20-, CD30-, CD43+, CD45+, lambda+) and lymphoma cells (CD20+, CD30+, CD43-, CD45-).
Findings:
- The large B-cell lymphoma component progressively predominated in neoplastic nodules.
- Both plasma cells and lymphoma cells expressed Epstein-Barr virus-encoded nuclear RNAs (EBER-1).
- Epstein-Barr virus-latent membrane antigen 1 (EBV-LMP1) was expressed in a subset of lymphoma cells but not plasma cells.
Implications:
- This case highlights a rare pathway of cutaneous plasmacytoma progression.
- Understanding distinct viral marker expression may aid in differentiating neoplastic components.
- The neoplastic process remained localized to the skin for over six years.
Abstract:
A unique, previously unreported case of transformation of cutaneous plasmacytoma into CD30+ large B-cell lymphoma is described. Both neoplastic components were immunophenotypically distinct. The plasma cells were CD20-, CD30-, CD43+, CD45+, lambda +; the blasts were CD20+, CD30+, CD43-, and CD45-. The large B-cell lymphoma has gradually become a predominant component of the neoplastic nodules. While plasma cells and blasts were both positive for Epstein-Barr virus-encoded nuclear RNAs (EBER-1), the EBV-latent membrane antigen 1 (EBV-LMP1) was expressed only in the minority of the blasts and not in the plasma cells. The neoplastic process has remained confined to the skin for more than six years since its development.
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