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Human herpes virus-8-negative primary effusion lymphoma in a patient with common variable immunodeficiency

Akiko Hisamoto1, Hiromichi Yamane, Akio Hiraki

  • 1Departament of Medicine, Sumitomo-Besshi Hospital, 3-1 Ojicho, Niihama, Ehime 792-0008, Japan. fwpg0506@mb.infoweb.ne.jp

Leukemia & Lymphoma
|January 24, 2004
PubMed

Insights

A rare cancer, primary effusion lymphoma (PEL), occurred in an HIV-negative patient with common variable immunodeficiency (CVID). This case challenges the known association of PEL with HIV and HHV-8, highlighting CVID as a risk factor.

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Primary effusion lymphoma (PEL) is a high-grade B cell lymphoma typically associated with human herpesvirus-8 (HHV-8) in individuals with human immunodeficiency virus (HIV).
  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia and an increased risk of malignancies.
  • The established link between PEL, HIV, and HHV-8 suggests specific etiological factors for this lymphoma subtype.

Observation:

  • A case of PEL developed in the pleural and pericardial cavities.
  • The patient was negative for both HIV and HHV-8.

Findings:

  • This PEL case occurred in an HIV-negative and HHV-8-negative individual.
  • The patient had a diagnosis of Common Variable Immunodeficiency (CVID).

Implications:

  • This case expands the known clinical spectrum of PEL.
  • It highlights the importance of considering rare malignancies in immunocompromised patients, even without typical risk factors.
  • Further research may be needed to understand PEL pathogenesis in non-HIV/HHV-8 contexts.

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