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Updated: Jul 30, 2026
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
[Immunoblastic lymphoma as expression of the final phase of IgA multiple myeloma]
E Pastor Rubín de Celis1, R J Ruiz Salmerón, M Aguirre Jaca
1Servicio de Medicina Interna y Anatomía Patológica, Facultad de Medicina, Universidad Autónoma, Madrid.
Insights
A patient with IgA multiple myeloma developed immunoblastic lymphoma in subcutaneous nodules. Despite treatment, the patient succumbed to pneumonia and digestive hemorrhage.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- IgA multiple myeloma is a plasma cell neoplasm.
- VCAP chemotherapy (vincristine, cyclophosphamide, doxorubicin, prednisone) is a standard treatment regimen.
Observation:
- A patient with IgA multiple myeloma presented with fever and constitutional symptoms.
- Multiple subcutaneous nodules developed during hospitalization.
- Bone marrow and nodule biopsies revealed immunoblastic lymphoma.
Findings:
- The patient experienced a transformation from IgA multiple myeloma to immunoblastic lymphoma.
- The patient's condition rapidly deteriorated despite treatment.
Implications:
- This case highlights a rare but aggressive transformation of multiple myeloma.
- Early recognition and understanding of such transformations are crucial for patient outcomes.
Abstract:
We present the case of a patient diagnosed of IgA multiple myeloma who, four months after being diagnosed and after four cycles with VCAP with good response, showed high fever and constitutional syndrome; multiple subcutaneous nodules appeared during his hospitalization. Biopsy of the bone marrow, and of one of the nodules showed an immunoblastic lymphoma. Even with treatment the patient died due to a pneumonia and a digestive hemorrhage.
