Related Experiment Video

Updated: Aug 25, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Cutaneous lymphoma in a juvenile dog

Ul Soo Choi1, Seong Mok Jeong, Min-Soo Kang

  • 1Department of Clinical Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.

Veterinary Clinical Pathology
|March 30, 2004
PubMed

Insights

This study reports the first case of a solitary nodular cutaneous lymphoma in a young Doberman Pinscher. The T-lymphocyte cancer was successfully treated with surgery, with no recurrence observed.

Area of Science:

  • Veterinary Oncology
  • Dermatopathology
  • Canine Neoplasia

Background:

  • Cutaneous lymphoma in dogs can present in various forms.
  • Early and accurate diagnosis is crucial for effective treatment and prognosis.
  • T-lymphocyte lymphoma is a significant subtype of canine lymphoma.

Observation:

  • An 18-month-old Doberman Pinscher presented with a solitary, erythematous, nodular skin mass on its forelimb.
  • Cytologic examination and histopathology confirmed the mass as cutaneous lymphoma.
  • Immunohistochemistry identified the neoplastic cells as T lymphocytes (CD3 positive, CD79a negative).

Findings:

  • The canine cutaneous lymphoma was a solitary nodular form, originating from T lymphocytes.
  • Surgical excision was performed for the mass.
  • No tumor recurrence was observed 18 months post-surgery, indicating successful treatment.

Implications:

  • This case highlights a rare presentation of canine cutaneous lymphoma in a young dog.
  • It underscores the importance of immunohistochemistry in differentiating lymphoma subtypes.
  • The successful surgical outcome suggests this may be a viable treatment option for solitary nodular forms.

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...