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Published on: March 30, 2018
[Primary low grade B-cell lymphoma MALT type of the duramater: case report]
Pedro Raso1, Eduardo Rossi Monteiro, Alexandre Tafuri
1Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. latafuri@terra.com.br
Insights
This report details a rare case of low-grade B-cell lymphoma in the dura mater. The MALT-type non-Hodgkin lymphoma showed favorable response to chemotherapy and radiotherapy.
Area of Science:
- Oncology
- Neuropathology
- Immunohistochemistry
Background:
- Malignant lymphomas, particularly extranodal types like mucosa-associated lymphoid tissue (MALT) lymphoma, can rarely involve the central nervous system.
- Primary dural lymphomas are exceptionally rare, presenting diagnostic and therapeutic challenges.
Observation:
- A 36-year-old woman presented with neurological symptoms attributed to a rare, primary dural tumor.
- The tumor exhibited nodular, low-grade non-Hodgkin malignant lymphoma, MALT type, with lymphoplasmocytic morphology.
- Immunohistochemical analysis confirmed a B-lymphocyte immunophenotype with monoclonal immunoglobulin kappa light chain restriction and a low proliferation index (<10%).
Findings:
- The resected tumor was identified as a primary dural, low-grade B-cell lymphoma, MALT type.
- The patient experienced positive clinical outcomes following surgical resection, chemotherapy, and radiotherapy.
Implications:
- This case highlights the importance of considering rare dural lymphomas in the differential diagnosis of intracranial masses presenting with neurological deficits.
- Multimodal treatment including surgery, chemotherapy, and radiotherapy can be effective for primary dural MALT lymphomas.
- Further research into the pathogenesis and optimal management of primary CNS lymphomas is warranted.
Abstract:
We describe a rare case of nodular and low grade non-Hodgkin malignant lymphoma, MALT type, with morphological and immunohistochemical features of lymphoplasmocytic (REAL classification), of immunophenotype of B lymphocytes and detected monoclonal of immunoglobulin kappa light chains, with low proliferation grade (<10%). The tumor was primitive of the left parietal duramater in a 36 years old woman, who presented neurological clinical symptoms four months before the surgery. After surgery, she was submitted to chemotherapy and radiotherapy with good results.
