Related Experiment Video

Updated: Aug 9, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Immunological evaluation of cefodizime: a unique molecule among cephalosporins

M T Labro1

  • 1INSERM U 294, Laboratoire d'Immunologie et d'Hématologie, CHU Xavier Bichat, Paris, France.

Infection
|January 1, 1992
PubMed

Insights

Cefodizime, an aminothiazolyl cephalosporin antibiotic, enhances immune cell functions and restores immunity in compromised hosts. This review highlights its dual role in fighting infections and modulating the immune system.

Area of Science:

  • Immunology
  • Pharmacology
  • Microbiology

Background:

  • Cefodizime is a novel aminothiazolyl cephalosporin.
  • Its immunomodulatory effects require comprehensive review.

Purpose of the Study:

  • To review the immunomodulatory properties of cefodizime.
  • To assess its impact on immune functions in various models.

Main Methods:

  • In vitro and ex vivo studies on phagocyte and lymphocyte functions.
  • Evaluation in immunocompromised animal and human models.
  • In vivo efficacy studies against sensitive and resistant pathogens.

Main Results:

  • Cefodizime stimulates phagocyte bactericidal activity.
  • It enhances lymphocyte responses, including delayed type hypersensitivity and antibody production.
  • The drug restores immune functions in immunocompromised subjects and shows efficacy in infection models.

Conclusions:

  • Cefodizime exhibits significant immunomodulatory effects.
  • It possesses potent antimicrobial activity and beneficial immune-modulating properties.
  • Cefodizime is a promising therapeutic agent for infections, with potential immune-enhancing benefits.

More Related Videos

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

Amikacin Protection Assay for Quantification and Visualization of Escherichia coli Cell Invasion09:22

Amikacin Protection Assay for Quantification and Visualization of Escherichia coli Cell Invasion

Published on: July 3, 2026

Related Concept Videos

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...