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Angiotropic large cell lymphoma
T Vougiouklakis1, A Mitselou, N J Agnantis
1Dept of Forensic Pathology, Medical School, University of Ioannina, Ioannina, Greece.
Insights
A man died from status epilepticus and respiratory failure. Autopsy revealed B-cell lymphoid cells infiltrating blood vessels, indicating a rare B-cell malignancy.
Area of Science:
- Hematology
- Neurology
- Oncology
Background:
- Status epilepticus is a neurological emergency.
- Acute respiratory failure can be a complication of critical illness.
- Intravascular lymphoid infiltrates are rare and can be challenging to diagnose.
Observation:
- A 67-year-old male presented with status epilepticus and expired due to acute respiratory failure.
- Autopsy revealed widespread intravascular infiltration by lymphoid cells.
- Histological examination and immunohistochemistry were performed.
Findings:
- Immunohistochemical studies showed positive staining for leukocyte common antigen (LCA), L26, and CD20.
- Negative staining for Factor VIII-related antigen and CD5 was observed.
- These findings confirmed the neoplastic cells were of B-cell lineage.
Implications:
- This case highlights a rare presentation of B-cell malignancy.
- Intravascular lymphoid infiltrates can lead to severe systemic complications.
- Early diagnosis and understanding of such rare conditions are crucial for patient outcomes.
Abstract:
A 67 year old man developed "status epilepticus" and died with acute respiratory failure. An autopsy and concomitant histological examination, revealed intravascular infiltrate of lymphoid cells throughout the body. Immunohistochemical studies showed intense positive staining for leukocyte common antigen (LCA), L26 and CD20 and negative staining for Factor VIII- related antigen, and CD5, demonstrated that the neoplastic cells were of B-cell lineage.
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