Related Experiment Videos
[From qualification to quantification in immunoserological testings]
1Department of Clinical Pathology, Iwate Medical University, Morioka.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 1, 1992
Insights
Quantifications of immunoserological tests like C-reactive protein advanced rapidly in the 1980s. However, significant interlaboratory variations highlight challenges in achieving reliable quantitative performance in immunochemical assays.
Area of Science:
- Clinical chemistry
- Immunology
- Laboratory medicine
Context:
- The 1980s saw significant advancements in immunoserological testing.
- Key tests include C-reactive protein (CRP), rheumatoid factor (RF), and antistreptolysin O (ASO).
- Despite progress, substantial interlaboratory variability was noted.
Purpose:
- To review the challenges in achieving accurate quantitative results in immunochemical assays.
- To discuss the difficulties in meeting performance standards for these tests.
Summary:
- Rapid progress in immunoserological test quantification occurred during the 1980s.
- Significant interlaboratory differences were observed for tests like CRP, RF, and ASO.
- The review focuses on the obstacles to obtaining reliable quantitative data.
Impact:
- Highlights the persistent challenges in standardization of immunochemical assays.
- Underscores the need for improved methods to ensure consistent and accurate diagnostic testing.
- Provides historical context for ongoing efforts in laboratory quality control.
Abstract:
During the 1980's, quantifications of immunoserological testings, especially C reactive protein, rheumatoid factor and antistreptolysin O, progressed rapidly. However, marked interlaboratory differences in these quantifications have been observed. In this brief review, difficulties to satisfy requirements for good quantitative performance in immunochemical assays are discussed.