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Updated: Aug 19, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
Ultrasound findings of iodide mumps
1Department of Radiology, Soonchunhyang University Bucheon Hospital, 1174, Jung-dong, Wonmi-gu, Bucheon-shi Gyeonggi-do, Republic of Korea.
Insights
Iodide mumps, a rare adverse reaction to contrast media, caused temporary submandibular gland swelling in a gastric cancer patient after a CT scan. Symptoms resolved within 24 hours.
Area of Science:
- Radiology
- Pharmacology
Background:
- Iodide mumps is an uncommon adverse event following iodinated contrast media administration.
- This case highlights a rare reaction in a patient undergoing advanced gastric cancer treatment.
Observation:
- A 73-year-old male with gastric cancer developed bilateral submandibular gland swelling approximately 10 minutes post-intravenous contrast injection.
- The swelling was progressive, accompanied by ultrasound findings of diffuse glandular enlargement and thickened septa.
Findings:
- The patient received 140 ml of low-osmolality contrast agent Ioxaglate.
- Submandibular gland swelling, a manifestation of iodide mumps, occurred as an acute, transient reaction.
Implications:
- This case underscores the importance of recognizing iodide mumps as a potential, albeit rare, complication of contrast-enhanced CT scans.
- Prompt recognition and understanding of the self-limiting nature of iodide mumps can aid in patient management and reassurance.
Abstract:
Iodide mumps, swelling of salivary glands after contrast medium injection, is a rare adverse reaction. We present a case in a 73-year-old man with advanced gastric cancer. About 10 min after a CT scan performed with intravenous injection of 140 ml of the low osmolality contrast agent Ioxaglate (Hexabrix 320, Guerbet, France), he complained of progressive swelling of the submandibular area. Ultrasound showed diffuse swelling and internal low echoic thick septa in the submandibular glands bilaterally. Approximately 1 h afterwards, the swelling of his submandibular glands started to regress and returned to normal within a day.
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