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[ICAM-1: structure, biological role and clinical significance]

Małgorzata Pietruczuk1, Adam Pietruczuk, Sławomir Pancewicz

  • 1Klinika Chorób Zakaźnych i Neuroinfekcji AM w Białymstoku.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|March 10, 2005
PubMed

Insights

Intercellular Adhesion Molecule-1 (ICAM-1) is crucial for leukocyte movement during inflammation. Soluble ICAM-1 levels in bodily fluids indicate its role in various infectious, autoimmune, and proliferative diseases.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Medicine

Context:

  • Intercellular Adhesion Molecule-1 (ICAM-1) is an immunoglobulin-like cell surface protein.
  • ICAM-1 mediates leukocyte adhesion and migration to inflammatory sites.
  • Expressed on endothelial cells and immune cells, ICAM-1 has both membrane-bound and soluble forms.

Purpose:

  • To elucidate the role of ICAM-1 in disease pathogenesis.
  • To highlight the clinical significance of ICAM-1.
  • To review the involvement of soluble ICAM-1 in various disease states.

Summary:

  • ICAM-1 is expressed on various cell types and is vital for leukocyte trafficking in inflammation.
  • Soluble ICAM-1 is detectable in serum and cerebrospinal fluid.
  • Elevated soluble ICAM-1 is associated with infectious, autoimmune, and proliferative diseases.

Impact:

  • Provides insights into ICAM-1's function in disease.
  • Underscores the clinical relevance of ICAM-1 as a biomarker.
  • Establishes the connection between ICAM-1 and pathogenesis in diverse conditions.

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