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Cerebral amyloidoma diagnosed intraoperatively with squash preparations: a case report
Karen Meir1, Bella Maly, Yigal Shoshan
1Department of Pathology, Hadassah University Hospital, Jerusalem, Israel.
Insights
This case report details the first cytologic findings of a rare central nervous system (CNS) amyloidoma. The study highlights diagnostic clues for this uncommon tumoral amyloidosis.
Area of Science:
- Neurology
- Pathology
- Radiology
Background:
- Amyloidoma, a rare form of central nervous system (CNS) amyloidosis, presents as a tumoral mass.
- Distinguishing CNS amyloidoma from other brain tumors can be challenging.
Observation:
- A 51-year-old woman presented with symptoms of otitis media and hearing loss.
- Imaging revealed a right temporal lobe mass, initially suspected to be glioma.
- Stereotactic biopsy was performed for diagnosis.
Findings:
- Cytologic examination of the biopsy was consistent with amyloidoma.
- Histologic and electron microscopic analyses confirmed the diagnosis.
- Systemic amyloidosis and plasma cell dyscrasia were excluded through further testing.
Implications:
- This report presents the initial cytologic findings for CNS amyloidoma.
- Accurate cytologic diagnosis can aid in early identification and management of this rare condition.
- Further research into CNS amyloidoma diagnostics is warranted.
Background:
Amyloidoma (tumoral amyloidosis) is the rarest form of central nervous system (CNS) amyloidosis.
Case:
A 51-year-old woman presented with recurrent right-sided otitis media and hearing loss. Computed tomography and magnetic resonance imaging revealed a mass in the right temporal lobe. Cytologic findings at the time of stereotactic biopsy for suspected glioma were compatible with amyloidoma. Subsequent histologic and electron microscopic findings confirmed the diagnosis of amyloidoma. Auxiliary testing ruled out systemic amyloidosis and plasma cell dyscrasia.
Conclusion:
To our knowledge, this is the first report on the cytologic findings in a case of CNS amyloidoma.