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Updated: Aug 10, 2026

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
10:12

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Published on: August 8, 2013

[A very high level in a cardiac troponin I assay]

C Corne1, M Durand, S Vergnaud

  • 1Département de biologie integrée. CCorne@chu-grenoble.fr

Annales De Biologie Clinique
|June 14, 2005
PubMed

Insights

This case report details an exceptionally high cardiac troponin I (cTnI) level following myocardial infarction and angioplasty. The massive cTnI release highlights its role as a sensitive marker for myocardial injury.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Medicine

Background:

  • Cardiac troponin I (cTnI) is a critical biomarker for detecting myocardial injury.
  • Elevated cTnI levels are indicative of cardiac necrosis and damage.

Observation:

  • A 64-year-old male presented with myocardial infarction, cardiac necrosis, and cytolysis.
  • Initial troponin assay upon hospitalization was normal.
  • Following angioplasty and coronary reperfusion, a massive release of cTnI was observed.

Findings:

  • Troponin I concentration exceeded 4000 microg/L, approximately 10 hours post-symptom onset.
  • This represents an exceptional TnIc concentration, potentially the highest reported value.
  • The baseline TnIc was 1.5 microg/L.

Implications:

  • This case underscores the potential for extreme cTnI elevations after reperfusion therapy in myocardial infarction.
  • Such findings emphasize the importance of serial cTnI monitoring in acute cardiac events.
  • Understanding these extreme biomarker dynamics aids in diagnosing and managing myocardial infarction.

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