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Updated: Aug 8, 2026

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

IgA Fc receptors in cattle and horses

H Craig Morton1

  • 1Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, Rikshospitalet University Hospital, N-0027 Oslo, Norway.. h.c.morton@medisin.uio.no

Veterinary Immunology and Immunopathology
|August 16, 2005
PubMed

Insights

The IgA receptor CD89 (FcalphaR) on leukocytes triggers immune responses. This review covers the structure and function of bovine and equine CD89, expanding knowledge of this important immune receptor in veterinary medicine.

Area of Science:

  • Immunology
  • Veterinary Medicine
  • Molecular Biology

Background:

  • Immunoglobulin A (IgA) plays a crucial role in mucosal immunity.
  • Leukocyte-surface receptors, FcalphaRs, mediate IgA's biological functions.
  • Human FcalphaR, CD89, is the first identified IgA Fc receptor, initiating effector functions like phagocytosis and ADCC.

Purpose of the Study:

  • To review the current understanding of bovine and equine CD89.
  • To explore the structure and function of FcalphaR in cows and horses.
  • To highlight the significance of CD89 in veterinary immunology.

Main Methods:

  • Literature review of existing studies on CD89.
  • Comparative analysis of CD89 orthologs in different species.
  • Summary of functional data related to IgA-Fc interactions.

Main Results:

  • CD89 orthologs have been identified in cattle and horses.
  • The structure and function of bovine and equine CD89 are being elucidated.
  • Understanding these receptors is key to IgA-mediated immunity in these species.

Conclusions:

  • Bovine and equine CD89 are crucial for IgA effector functions.
  • Further research into CD89 in veterinary species will advance immunology.
  • FcalphaR knowledge in cows and horses has implications for animal health and disease research.

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