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Updated: Jan 4, 2026
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
[Clinical analysis of histocytic necrotizing lymphadenitis]
Min-fei Pei1, Xiao Zhu, Guang-sen Zhang
1Department of Hematology,Second Xiangya Hospital, Central South University, Changsha 410011, China. peiminfei@tom.com
Insights
Histiocytic necrotizing lymphadenitis (HNL) primarily affects young females, presenting with lymphadenopathy and fever. Recognizing its distinct histopathology is crucial to avoid misdiagnosis as lymphoma or tuberculosis.
Area of Science:
- Pathology
- Oncology
- Immunology
Context:
- Histiocytic necrotizing lymphadenitis (HNL) is a rare condition.
- Accurate diagnosis is essential for appropriate patient management.
Purpose:
- To elucidate the clinical and histopathological characteristics of HNL.
- To improve the recognition of HNL in clinical practice.
Summary:
- Retrospective analysis of 10 HNL cases revealed common symptoms including lymphadenopathy and fever, predominantly in young females.
- Histopathology is characterized by necrosis with surrounding histiocytic proliferation, typically lacking neutrophils.
- Associated connective tissue diseases were noted in some patients.
Impact:
- Understanding HNL's features aids in differentiating it from malignancies like lymphoma and infections such as tuberculosis.
- Highlights the importance of histopathological examination for accurate HNL diagnosis.
- Suggests HNL has a generally favorable prognosis when correctly identified.
Objective:
To understand the clinical features and histopathology of histocytic necrotizing lymphadenitis (HNL) so as to better recognize the disease.
Methods:
The clinical features, histopathology, and diagnosis of 10 patients admitted to our hospital were retrospectively analyzed.
Results:
The clinical features of these 10 cases included: young females were the majority; lymphadenopathy and fever were the most common clinical manifestations; some cases were accompanied by connective tissue diseases. Histopathologic examination showed distinctive necrosis and around the necrotic foci, variable proliferations of histocytes but generally without infiltration of neutrophils.
Conclusion:
HNL has some typical histopathological alterations and relatively fine prognosis,but it tends to be misdiagnosed as lymphoma or lymphoid tuberculosis and may be accompanied by other diseases.
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