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A primary follicular lymphoma of the duodenum treated successfully with radiation therapy

Masaaki Takamura1, Rintaro Narisawa, Yudzuru Maruyama

  • 1Department of Gastroenterology and Hepatology, Niigata University, Graduate School of Medical and Dental Sciences, Asahimachi-dori.

Internal Medicine (Tokyo, Japan)
|April 6, 2006
PubMed

Insights

A rare duodenal follicular lymphoma (FL) was diagnosed in a 48-year-old man. This early-stage cancer responded well to radiation, with the patient remaining in remission for three years.

Area of Science:

  • Gastrointestinal Oncology
  • Hematologic Malignancies
  • Diagnostic Pathology

Background:

  • Follicular lymphoma (FL) is a type of non-Hodgkin lymphoma that typically affects lymph nodes.
  • Primary duodenal FL is an uncommon extranodal manifestation of this B-cell lymphoma.

Observation:

  • A 48-year-old male presented with recurrent epigastric pain.
  • Endoscopy revealed multiple whitish granules in the second and third portions of the duodenum.
  • Biopsies showed a monotonous population of small cleaved cells positive for CD20, CD10, and BCL2, consistent with FL.

Findings:

  • The patient was diagnosed with stage I, grade 1 follicular lymphoma of the duodenum based on WHO classification.
  • Staging studies showed no evidence of disseminated disease.
  • The patient achieved complete remission after localized irradiation.

Implications:

  • This case highlights the importance of considering duodenal follicular lymphoma in patients with unexplained duodenal lesions.
  • Early diagnosis and localized treatment can lead to favorable outcomes in early-stage duodenal FL.
  • Increased recognition of duodenal FL suggests a need for heightened clinical awareness and diagnostic scrutiny.

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