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Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia and does not

Mihai Merzianu1, Liuyan Jiang, Pei Lin

  • 1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|April 26, 2006
PubMed

Insights

Nuclear B-cell lymphoma 10 (BCL-10) expression is common in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM), occurring in 55% of cases. This finding is independent of MALT lymphoma-associated translocations and NF-kappaB activation.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • B-cell lymphoma 10 (BCL-10) is crucial for lymphocyte development and activation, with aberrant nuclear expression linked to certain lymphomas.
  • Its role in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) remains largely uncharacterized.

Purpose of the Study:

  • To investigate the expression patterns of BCL-10 in bone marrow specimens of patients with LPL/WM.
  • To assess the correlation of BCL-10 expression with disease extent and nuclear factor-kappa B (NF-kappaB) activation.

Main Methods:

  • Immunohistochemical analysis of BCL-10 and p65 NF-kappaB subunit in 51 LPL/WM bone marrow specimens.
  • Assessment of BCL-10 expression extent and pattern within neoplastic B-cells.
  • Cytogenetic analysis for specific translocations (t(1;14) and t(11;18)) in a subset of cases.

Main Results:

  • Nuclear BCL-10 staining was observed in 55% (28/51) of LPL/WM specimens.
  • BCL-10 expression significantly correlated with a greater extent of bone marrow involvement (P=0.001).
  • Nuclear p65 NF-kappaB was detected in 34% (17/50) of cases, but did not correlate with BCL-10 expression or MALT lymphoma-associated translocations.

Conclusions:

  • Nuclear BCL-10 expression is a frequent finding in LPL/WM.
  • The presence of nuclear BCL-10 in LPL/WM is not associated with the translocations typically seen in MALT lymphomas.
  • NF-kappaB pathway activation occurs in a subset of LPL/WM but is not directly linked to nuclear BCL-10 staining in this cohort.

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