[Effort in standardization of control survey using pooled fresh serum in Okayama Prefecture]
Ken Okada1, Norio Koide, Katsunori Kohguchi
1Department of Central Clinical Laboratory, Okayama University Hospital of Medicine and Dentistry, Okayama 700-8558.
Insights
A new monthly Okayama cross-check program using fresh pooled serum was developed to improve clinical laboratory data accuracy. This initiative reduces laboratory test result differences, enhancing diagnostic reliability across Okayama Prefecture.
Area of Science:
- Clinical chemistry
- Laboratory medicine
- Quality control
Context:
- Annual control surveys using commercial serum for 18 years in Okayama Prefecture.
- Limitations of annual surveys in detecting data discrepancies and method-specific variations (e.g., dry vs. wet chemistry).
- Matrix effects influencing control serum accuracy.
Purpose:
- To minimize laboratory test data differences among facilities.
- To address the inadequacy of annual surveys and commercial control serum.
- To develop and evaluate a more effective monthly cross-check program.
Summary:
- Developed the Okayama cross-check program, a monthly survey utilizing pooled fresh serum from regional hospitals and commercial labs.
- Implemented the program to overcome limitations of annual surveys and commercial control serum, particularly matrix effects.
- Detailed the program's methodology and assessed its effectiveness in reducing inter-laboratory variations.
Impact:
- Successfully reduced differences in laboratory test results among participating facilities.
- Enhanced the reliability and comparability of clinical laboratory data within Okayama Prefecture.
- Demonstrated the value of a collaborative, monthly fresh serum-based quality control program.
Abstract:
Control survey of the clinical laboratories in Okayama Prefecture has been continued once a year for 18 years using commercially available control serum. The purpose of our control survey is to minimize the difference of laboratory test data among laboratories. It is clear, however, that one time a year survey leads to miss-evaluation of the difference in laboratory test result. Furthermore the data difference caused by difference of assay methods, for example dry chemistry and wet chemistry, is not properly evaluated by control survey using control serum, since test result is affected by matrix effect. Therefore we have developed a monthly control survey program, Okayama cross-check program, using pooled fresh serum among laboratories of middle-large scale hospitals and commercial laboratories in Okayama prefecture. In this paper we describe the details of Okayama cross-check program and the usefulness of the program to reduce the difference among laboratory facilities. This result was attained by cooperation of the Okayama prefectural medical association, Okayama association of medical technologists, and commercial laboratories in Okayama.
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