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Updated: Aug 8, 2026
Isolation and Identification of Limbal Niche Cells
Published on: October 27, 2023
Isolated corneal intraepithelial neoplasia
Orasa Horatanaruang1, Orathai Chansanti, Winyou Mitarnun
1Department of Ophthalmology, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand. orasaho@yahoo.com
Insights
Isolated corneal intraepithelial neoplasia, a rare condition, was effectively treated in two patients using corneal epithelial scraping. This method showed no recurrence, suggesting its potential efficacy for this ocular surface disease.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Corneal intraepithelial neoplasia (CIN) is a premalignant lesion of the ocular surface.
- CIN typically arises from the corneoscleral limbus.
Observation:
- This report details two rare cases of isolated corneal intraepithelial neoplasia.
- The lesions in these cases did not originate from the corneoscleral limbus.
Findings:
- Both patients underwent corneal epithelial scraping for treatment.
- Histopathological examination confirmed the diagnosis in both cases.
- No recurrence of the neoplasia was observed post-treatment in either patient.
Implications:
- Isolated corneal intraepithelial neoplasia is an uncommon presentation.
- Corneal epithelial scraping appears to be a viable and effective treatment option.
- Further research into non-limbal CIN is warranted.
Objectives:
To report two cases of isolated corneal intraepithelial neoplasia.
Material And Method:
The present study included 2 cases presenting with isolated corneal intraepithelial neoplasia. Both patients were treated by corneal epithelial scraping.
Results:
The authors present the clinical picture and histopathological findings of 2 patients suffering from corneal intraepithelial neoplasia that did not arise from the corneoscleral limbus. Both patients showed no recurrence after treatment for a period of time.
Conclusion:
Isolated corneal intraepithelial neoplasia is rare. Corneal scraping may be an effective treatment.
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