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IgG4-associated prostatitis complicating autoimmune pancreatitis

Yukihiro Yoshimura1, Shin-ichi Takeda, Yasuhiko Ieki

  • 1Department of Internal Medicine, Kurobe City Hospital, Kurobe, Toyama.

Internal Medicine (Tokyo, Japan)
|September 2, 2006
PubMed

Insights

This study reports the first case of IgG4-associated prostatitis complicating autoimmune pancreatitis in a man with benign prostatic hypertrophy. The condition presented with obstructive jaundice and elevated IgG4 levels.

Area of Science:

  • Immunology
  • Gastroenterology
  • Urology

Background:

  • Immunoglobulin G4 (IgG4)-related disease is a systemic fibroinflammatory condition.
  • Autoimmune pancreatitis (AIP) is a manifestation of IgG4-related disease.
  • Benign prostatic hypertrophy (BPH) is a common condition in older men.

Observation:

  • A 65-year-old man with BPH developed obstructive jaundice post-prostate and salivary gland resection.
  • Laboratory tests revealed elevated eosinophils and serum IgG4 levels.
  • Histological examination of the prostate, salivary glands, and pancreas showed lymphocyte and plasma cell infiltration with dense fibrosis, predominantly IgG4-positive plasma cells.

Findings:

  • The patient was diagnosed with IgG4-associated prostatitis complicating autoimmune pancreatitis.
  • This represents the first documented case of this specific combination.

Implications:

  • This case highlights the potential for IgG4-related disease to affect the prostate.
  • It underscores the importance of considering IgG4-related disease in patients with unexplained obstructive jaundice and elevated IgG4.
  • Further research is needed to understand the pathogenesis and clinical spectrum of IgG4-related prostatitis.

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