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[Interleukin 2 concentration changes in the laryngeal cancer patients during the surgical treatment]
Jan Pilch1, Grzegorz Namysłowski, Wojciech Scierski
1Katedra i Oddział Kliniczny Laryngologii Slaskiej Akademii Medycznej w Zabrzu.
Insights
Serum levels of interleukin-2 (IL-2) were lower in laryngeal cancer patients before surgery compared to healthy individuals. Post-surgery, IL-2 levels significantly increased, surpassing those in the healthy control group.
Area of Science:
- Immunology
- Oncology
- Biochemistry
Background:
- Cytokines, including interleukin-2 (IL-2), regulate immune responses and cell proliferation.
- IL-2 plays an indirect anticancer role by stimulating cytotoxic immune cells.
- IL-2 is produced by T-helper lymphocytes and promotes their activation and cytokine production.
Purpose of the Study:
- To evaluate serum IL-2 concentrations in laryngeal cancer patients before and after surgical treatment.
- To compare IL-2 levels in laryngeal cancer patients with a healthy control group.
Main Methods:
- Serum IL-2 levels were measured in 22 male laryngeal cancer patients before surgery.
- IL-2 concentrations were assessed on day 1 and day 30 post-surgery.
- Results were compared to a control group of 20 healthy volunteers.
Main Results:
- Pre-treatment IL-2 levels in laryngeal cancer patients (23.4 pg/ml) were lower than in the healthy control group.
- IL-2 levels increased significantly to 37.8 pg/ml at 1 day and 54.3 pg/ml at 30 days post-surgery.
- Post-treatment IL-2 levels exceeded those of the healthy population.
Conclusions:
- Laryngeal cancer patients exhibit lower serum IL-2 concentrations pre-treatment compared to healthy individuals.
- Surgical intervention leads to a significant increase in serum IL-2 levels.
- Post-surgical IL-2 levels in these patients become higher than in the healthy control group.
Introduction:
Cytokines are molecules that regulate the process of differentiation and proliferation. They are also the mediators of immunological and inflammatory reactions. One of the cytokines that participates in immunological processes is interleukine-2 (IL-2), whose participation in neoplastic processes has been proved in many researches. It's anticancer effect is an indirect one and is connected with stimulating processes of immunologically competent cells, which are cytotoxic for cancer cells. IL-2 is produced by T-helper lymphocytes (THL), and on the basis of feedback it stimulates those lymphocytes to new cells and other cytokines, which stimulate next immunity cells or kill the cancer cells, production. The aim of the study was to evaluate the serum level concentration of IL-2 in the laryngeal cancer patients before any medical treatment and its denotation after the surgical procedure.
Material And Methods:
A group of 22 male patients with laryngeal cancer was considered for the purpose of this study. All of them were treated by surgery. In all the cases the serum concentration of IL-2 before the treatment, in the first and 30th day after therapy was evaluated. The results were compared with the group of 20 healthy volunteers.
Results:
The mean value of IL-2 concentration in laryngeal cancer patients treated by surgery was 23.4 pg/ml before treatment, increased to 37.8 pg/ml in the 1 day and to 54.3 pg/ml 30 days after the therapy. The serum concentrations of IL-2 in the laryngeal cancer patients were lower than in the control group before the surgical treatment. These IL-2 concentrations increased significantly after the surgery and 1 month after the treatment were higher than in the healthy population.
Conclusion:
The serum concentration of IL-2 in the laryngeal cancer patients treated by surgery is lower than in the healthy control group. IL-2 increased significantly after the surgery to higher levels than in the control healthy group.