Related Experiment Video

Updated: Aug 8, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

Serum soluble interleukin-2 receptor is associated with clinical and pathologic disease status in hairy cell leukemia

J M Richards1, R Mick, J M Latta

  • 1Department of Medicine, University of Chicago, IL 60637.

Blood
|November 15, 1990
PubMed

Insights

Soluble interleukin-2 receptor (sIL-2R) levels in hairy cell leukemia patients correlate with disease status. Declining sIL-2R indicates treatment response, while increasing levels suggest disease progression.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Hairy cell leukemia (HCL) is a B-cell chronic lymphoproliferative disorder.
  • Malignant cells in HCL express the interleukin-2 (IL-2) receptor.
  • Elevated soluble IL-2 receptor (sIL-2R) levels are found in HCL patient sera.

Purpose of the Study:

  • To investigate the association between serum sIL-2R levels and clinical status in HCL patients.
  • To evaluate sIL-2R as a potential biomarker for treatment response and disease progression in HCL.

Main Methods:

  • Analysis of 427 serum samples from 101 HCL patients for sIL-2R levels.
  • Correlation of sIL-2R levels with the hairy cell index (tumor cell burden).
  • Monitoring sIL-2R levels in relation to clinical status and response to various therapies.

Main Results:

  • Serum sIL-2R levels were significantly correlated with the hairy cell index (r = .77).
  • Decreasing sIL-2R levels were associated with improved clinical status and treatment response.
  • Increasing sIL-2R levels were linked to disease relapse and progression across different treatments.

Conclusions:

  • Serum sIL-2R is a reliable indicator of clinical status in hairy cell leukemia.
  • sIL-2R levels dynamically reflect treatment efficacy and disease activity.
  • Further prospective evaluation is underway to confirm the predictive reliability of sIL-2R testing.

More Related Videos

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD22608:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...