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A Heterotopic Mouse Model for Studying Laryngeal Transplantation
Published on: January 13, 2023
Septal graft in laryngeal reconstruction
Abdulrahman Bahannan1, Ales Slavicek, Milos Taudy
1Department of Otorhinolaryngology and Head and Neck Surgery, Faculty Hospital Motol, Prague, Czech Republic. dulman6@seznam.cz
Insights
A 62-year-old woman with chondrosarcoma of the larynx underwent successful reconstruction using a nasal septum mucocartilaginous graft. This technique preserved laryngeal functions after radical resection, offering a viable option for large defects.
Area of Science:
- Otolaryngology
- Surgical Oncology
- Medical Imaging
Background:
- Laryngeal chondrosarcoma is a rare malignancy requiring complex surgical management.
- Reconstruction of large laryngeal defects presents significant challenges to preserving function.
- Early diagnosis and appropriate surgical intervention are crucial for laryngeal cancer patients.
Observation:
- A 62-year-old female presented with dyspnea, and imaging revealed a mass involving the cricoid cartilage, thyroid gland, and thyroid cartilage.
- Cytology and biopsy confirmed Grade 1 chondrosarcoma.
- The patient underwent radical resection and immediate reconstruction using a mucocartilaginous graft from the nasal septum.
Findings:
- The mucocartilaginous graft successfully reconstructed the laryngeal skeleton defect.
- All laryngeal functions were preserved postoperatively.
- A salvage total laryngectomy was required 28 months later due to advanced local recurrence.
Implications:
- Nasal septum cartilage is a feasible graft material for functional reconstruction of extensive laryngeal defects.
- This technique offers a relatively straightforward method for laryngeal reconstruction.
- Despite successful initial reconstruction, long-term surveillance is essential due to the risk of recurrence.
Abstract:
A 62-year-old woman presented with symptoms of dyspnea. Ultrasonography and computed tomography examinations revealed mass extending from the cricoid cartilage to the left lobe of thyroid gland and thyroid cartilage. Cytology revealed possibility of cartilaginous origin, which was proven to be chondrosarcoma Grade 1 from the biopsy specimen obtained during panendoscopy. She underwent one stage radical resection and immediate reconstruction of laryngeal skeleton defect by mucocartilaginous graft from the nasal septum. Her postoperative course was optimal with preservation of all the laryngeal functions. Twenty-eight months postoperatively, she had to undergo total laryngectomy as a salvage procedure for the advanced local recurrence. We report on the relatively easy technique for functional reconstruction of the large laryngeal defect with the employment of cartilage graft from the nasal septum.
