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Updated: Aug 8, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Application of interferons in the control of infectious diseases of cattle
L A Babiuk1, L M Sordillo, M Campos
1Veterinary Infectious Disease Organization, Saskatoon, SK, Canada.
Insights
Interferons show potential in reducing cattle diseases like bovine respiratory disease and mastitis by modulating immune responses. Further research is needed to overcome challenges for their widespread clinical application.
Area of Science:
- Veterinary Immunology
- Infectious Disease Research
- Cytokine Therapeutics
Background:
- Immune system recovery from infection relies on cell interactions mediated by cytokines.
- Cytokines activate immune cells to combat pathogens, influencing disease progression.
Purpose of the Study:
- To review the application of interferons in managing bovine respiratory disease and mastitis.
- To discuss the potential and limitations of using interferons for disease modulation in cattle.
Main Methods:
- Review of existing literature on interferon applications in veterinary medicine.
- Analysis of in vitro and in vivo studies investigating cytokine mechanisms.
Main Results:
- Interferons can reduce morbidity and mortality in cattle affected by specific infections.
- The review highlights the therapeutic potential of interferons in veterinary contexts.
Conclusions:
- Interferons represent a promising therapeutic avenue for bovine respiratory disease and mastitis.
- Obstacles to the clinical use of interferons in cattle require further investigation and resolution.
Abstract:
Recovery from infection involves a number of complex interactions between specific cells of the immune system. Many of these interactions are mediated by cytokines, which can activate these cells to kill or reduce the replication rate of the pathogen. Availability of large quantities of recombinant cytokines has provided the opportunity to investigate the mechanism or mechanisms of action of each cytokine in vitro and in vivo. In the present review, we describe the application of interferons to reduce morbidity and mortality of cattle suffering from bovine respiratory disease and mastitis. The potential application of interferons in disease modulation as well as the impediments to their use are discussed.
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