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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
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Published on: March 1, 2011

[Usefulness of interleukin 18 determination in clinical diagnostics]

Beata Kuśnierz-Cabala1, Danuta Galicka-Latała, Jerzy W Naskalski

  • 1Zakład Diagnostyki, Katedra Biochemii Klinicznej, Collegium Medicum Uniwersytet Jagielloński w Krakowie. mbkusnie@cyf-kr.edu.pl

Przeglad Lekarski
|May 8, 2007
PubMed

Insights

Interleukin-18 (IL-18), a key proinflammatory cytokine, is crucial in inflammatory processes. Its determination is increasingly valuable for clinical diagnostics, aiding in understanding disease progression.

Area of Science:

  • Immunology
  • Cytokine Biology

Context:

  • Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine.
  • IL-18 was identified in 1995 as a potent inducer of interferon-gamma.
  • It influences various immune cells, including Kupffer cells, macrophages, T cells, and B cells.

Purpose:

  • To review current literature on the clinical diagnostic utility of Interleukin-18 (IL-18) determination.
  • To highlight the role of IL-18 in the inflammatory cascade.

Summary:

  • This review focuses on the diagnostic applications of measuring Interleukin-18 (IL-18) levels.
  • Recent publications demonstrate the significance of IL-18 in various clinical settings.

Impact:

  • Provides insights into the diagnostic potential of IL-18.
  • Supports the use of IL-18 as a biomarker in clinical practice.
  • Enhances understanding of IL-18's role in inflammatory diseases.

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